Publications & News

There is wide acceptance within the  cancer research community that the human tumor microenvironment and knowledge of the immune response within this environment holds the key to understanding the protective tumor immunity and to explaining why some cancer patients respond well to immune therapy and others do not. It has become increasingly apparent that the dynamic interaction between tumor cells and patient's immune cells, particularly T cells, is responsible for the tumor's escape from immune surveillance that ultimately results in tumor progression and metastasis.*

*Zou, W., Wolchok, J.D. and Chen, Lieping, Science Translational Medicine, March 2016, 8:328, pp1-14.

Other Selected Scientific Publications:

Yokota, S.J., Facciponte, J.G, Kelleher, Jr., Shultz, L.D., Loyall, J.L., Parsons, R.R., Odunsi, K., Frelinger, J.G., Lord, E.M., Gerber, S.A., Balu-lyer, S.-V. and Bankert, R.B.. Changes in ovarian tumor cell number, tumor vasculature and T cell function monitored in vivo using a novel xenograft model. Cancer Immunity 13: p.11/ May 31, 2013.

Simpson-Abelson, M.R., Loyall, J.L., Lehman, H.K., Barnas, J.L., Minderman, H., O’Loughlin, K.L., Wallace, P.K., George, T.C., Peng, P., Kelleher, Jr., R.J., Odunsi, K. and Bankert, R.B. Human ovarian tumor ascites fluids rapidly and reversibly inhibit T cell receptor- induced NF- kB and NFAT signaling in tumor- associated T cells. Cancer Immunity 13: p. 14, July 15, 2013.

Kelleher, Jr., R.J., Balu-lyer, S.-v., Loyall, J.L., Sacca, A.J., Shenoy, G.N., Peng, P., lyer, V., Fathallah, A.M., Berenson, C.S., Wallace, P.K., Tario, J., Odunsi, K. and Bankert, R.B. Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine- Dependent Arrest in the T-cell signalling Cascade. Cancer Immunology Research Nov. 2015, Volume 3 #11 pp 1269-1278

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